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Quest believes that it can apply its portfolio of oncology product candidates to prolong, amplify and shape anti-tumor immune responses to increase the clinical benefits of its proprietary antibodies for the treatment of cancer. The following modalities are critical to that approach:

Chemo Enhanced Immuno-Therapy - combining antibodies with front-line chemotherapy can potentially further complement and enhance the treatment outcome compared to antibody treatment alone.

SonoLight Technology – is based on a unique non-toxic family of photosensitizing and sonosensitizing, small molecular weight compounds called Hypocrellin, isolated from a parasitic fungus that grows on bamboo trees in China. Quest’s products are expected to offer high selectivity and efficacy with minimal side effects. Quest is also developing these compounds as an adjuvant to cancer immunotherapy.

Combination Therapy – combining antibodies with a booster compound (adjuvant) that improves the immune system’s response – compared to antibody treatment alone - can potentially complement and enhance the therapeutic outcome.

Antibody Monotherapy – uses the body’s immune system to reject cancer through the administration of therapeutic antibodies, which recruit the patient's immune system to destroy tumor cells. These antibodies can also be used as a vehicle to carry cytotoxic agents such as therapeutic radioisotopes.

Product Candidates Chemo Enhanced Immunotherapy (ovarian cancer - post surgery) Combination Therapy with Immuno-Adjuvant (ovarian cancer - watchful waiting)

SLO52
(prostate cancer - localized)

Market
  • Annual number of new cases (US) : ~ 25,000
  • Prevalence: 193,000
  • Treatment depends on the stage, grade, and how successful the surgery was at reducing the amount of cancer
  • Current standards of care cause significant collateral damage
  • One of six men will be diagnosed with prostate cancer in their lifetime
Current Status
  • Oregovomab being evaluated in combination with front-line chemotherapy
  • Pre-clinical studies for Oregovomab in combination with an adjuvant have been completed
  • Preclinical studies completed
  • No collateral damages or toxicity
  • Health Canada approval to commence Phase I Trial
Upcoming
Milestones
  • Initiate a Phase IIb clinical trial with front-line chemotherapy
  • Initiate a Phase I / II clinical trial in “watchful waiting” period
  • Dose first patient