Combination Therapy

Adjuvants: A booster compound that improves the immune system’s response to the vaccine.

Immunotherapy in Combination with PDT

• Collaboration with Dr. Korbelik, BCCA)
• Improved tumor free survival in mouse model
• Involvement of Cytotoxic T-Cells
• Strong Intellectual Property
• Immunotherapeutic Agents Tested:
• Cytokines, BCG, Fcg receptor antibody, autologous cancer vaccine

Future Studies

• Immuno-PDT Treatment of Non-Small Cell Lung Cancer (NSCLC)
• MUC1 over-expressed in many cancers such as NSCLC

Korbelik et al (2009) Exploitation of immune response-eliciting properties of hypocrellin photosensitizer SL052-based photodynamic therapy for eradication of malignant tumors. Photochem Photobio 2009 Nov-Dec;85(6):1418-24.

Immunotherapy in Combination with Adjuvants

• Adjuvant Used: Poly: C12U (TLR-3 Agonist)
• Antibody Used: Anti- PSA
• Animal Model: PSA Transgenic Mouse Model
  
  Results:
  PSA specific T cell and antibody responses were significantly enhanced

Nicodemus et al (2009) Toll Like Receptor-3 as Target to Enhance Bioactivity of Cancer Immunology. Am J Obstet Gynecol (In-press)